Fluorosome®trans Data

The validity of the Fluorosome method was first demonstrated by permeability assays with 44 marketed drugs of documented low, medium and high human oral absorption. These drugs have diverse structures and properties, are from a variety of therapeutic classes, and are believed to be absorbed by passive diffusion. Membrane permeability coefficients of these drugs were measured and compared with human oral absorption values. A plot of Fluorosome-trans-pgp data with the human oral absorption values is seen in Example 1. An R value of 0.87 demonstrates the high correlation between Fluorosome-trans obtained permeability constants and oral absorption. The Fluorosome-trans technique gives a higher correlation of permeability constants to oral absorption than PAMPA determinations and a tighter fit than Caco-2 determinations.

Example 1:  Correlation between permeability measured with Fluorosome®trans and oral absorption for 44 drugs.

tfcbio-trans examples

Example 2:  Comparison of PAMPA () and Fluorosome®trans () correlations for 22 drugs.

tfcbio-trans examples

Example 3:  Comparison of Caco-2 () and Fluorosome®trans () correlations for 27 drugs.

tfcbio-trans examples